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Winner B, Lie DC, Rockenstein E, Aigner R, Aigner L, Masliah E, et al
Fluid retention dark circles manifest as puffiness from lymphatic drainage impairment, salt intake causing water retention, allergies triggering histamine response and swelling, or sleeping position allowing fluid accumulation
Note worthily, BH 4 depletion-driven eNOS uncoupling may rather be secondary to the oxidation of zinc-thiolate cluster of eNOS
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